Comprehensive meta analysis serial number

Regarding the serotonergic system, there is strong evidence supporting its role in MD and in other mood disorders based on available pharmacological treatments. Moreover, several studies have reported a reduction of dopaminergic receptor density in several brain regions of ADHD patients, which is in agreement with the mechanism of action of the ADHD treatments, like methylphenidate or amphetamine, that enhance dopamine transmission in prefrontal cortex. chlorpromazine and haloperidol), and some of them are combined with serotonin 5-HT2A receptor antagonists (e.g. Therefore, most of the antipsychotic treatments block the dopamine D 2 receptor (e.g. For example, the positive symptoms of SCZ seem to be associated with hyperdopaminergic neurotransmission, especially in the mesolimbic system, while the negative symptoms and cognitive deficits might be caused by hypodopaminergic activity in the mesocortical pathway. motor control, cognition, motivation, regulation of emotions or reward), and have been related to the physiopathology and treatment of many psychiatric disorders.Дopaminergic dysfunction has been described in ADHD, ASD, OCD, TS, SCZ, mood disorders, and substance use disorders (SUD) among others. Дopamine (DA) and serotonin (SERT) are two important neurotransmitters that participate in the regulation of a wide range of essential functions of the organism (e.g. These results suggest that the high levels of comorbidity found in psychiatric disorders may be explained, at least in part, by shared genetic risk factors, supporting the existence of a set of genes that confer relatively broad liability to psychiatric disorders. Recent studies have shown strong genetic correlations among psychiatric phenotypes, and the latest genome-wide association study (GWAS) meta-analysis conducted on eight psychiatric disorders (attention-deficit hyperactivity disorder (ADHD), anorexia nervosa (ANO), autism spectrum disorder (ASD), bipolar disorder (BIP), major depression (MD), obsessive-compulsive disorder (OCD), schizophrenia (SCZ) and TouretteвЂ™s syndrome (TS)) found that 75% of the LD-independent associated regions (109 out of 146) were associated with more than one disorder. Interestingly, psychiatric disorders display considerable clinical overlap among them, and the presence of comorbidity is associated with increased severity and difficulty of treatment. They constitute a set of complex traits that result from the interaction of genetic and environmental risk factors, with heritability ranging from 40 to 80%, depending on the disorder, as estimated by twin studies. Psychiatric disorders represent a major health problem, affecting 29.2% of the worldwide population at some point during their lifetime, and are associated with considerable distress and functional impairment. Our results support a pleiotropic contribution of the dopaminergic and serotonergic systems in several psychiatric conditions. To our knowledge, this is the first systematic examination of genes encoding proteins essential to the function of these two neurotransmitter systems in these disorders. Interestingly, interrogation of a cross-disorder GWAS meta-analysis of the eight psychiatric conditions displayed association with the wide DA gene set. Gene-set analysis revealed significant associations for ADHD and ASD with the wide DA gene set, for BIP with the wide SERT gene set, and for MD with the core SERT set. At the gene level, we found 67 genes from the DA and/or SERT gene sets significantly associated with one of the studied disorders, and 12 of them were associated with two different disorders. To do so, we elaborated four different gene sets: two вЂwideвЂ™ selections for dopamine (DA) and for serotonin (SERT) using the Gene Ontology and KEGG pathways tools, and twoвЂ™coreвЂ™ selections for the same systems, manually curated. Here we aim to assess the genetic contribution of these systems to eight psychiatric disorders (attention-deficit hyperactivity disorder (ADHD), anorexia nervosa (ANO), autism spectrum disorder (ASD), bipolar disorder (BIP), major depression (MD), obsessive-compulsive disorder (OCD), schizophrenia (SCZ) and TouretteвЂ™s syndrome (TS)) using publicly available GWAS analyses performed by the Psychiatric Genomics Consortium that include more than 160,000 cases and 275,000 controls. Dopaminergic and serotonergic neurotransmission have been shown to play an important role in many psychiatric disorders. Psychiatric disorders are highly prevalent and display considerable clinical and genetic overlap.

Comprehensive meta analysis serial number